(BIO)PROCESS ENGINEERING GROUP, IIM-CSIC, Vigo, Spain
Research Profile and Publications (2005-2010)
Mathematical modelling, simulation,
optimization and control of bioprocesses
The main overall objective of this research line is to
improve the efficiency of bioprocesses via systems
engineering methods. These methods are based on a model-driven systemic
approach, i.e. they make extensive use of mathematical
models and simulation, optimization and control methods and tools (software).
The ultimate goal is to improve the efficiency of
these processes and the quality and safety of their products, reducing energy
and water consumption and environmental impact.
There are two main blocks of objectives:
1. methods:
to develop robust and efficient methods and tools (software) for the
multi-scale mathematical modeling, simulation, optimization, monitoring and
control of bioprocesses
2. applications:
to apply these methods and tools to real processes and systems of clear
interest, such as industrial processes of high economic importance (food and
biotechnological sectors), and relevant biosystems associated with them (systems
biology of microorganisms)
2010
Papers in Journals
J. Ross, A. Fernández Villaverde, S. Vázquez, J.R.
Banga, F. Morán. Julio 2010. A generalized Fisher equation and its
utility in chemical kinetics. Proceedings
of the National Academy of Sciences of the USA. 107: 12777-12781
Balsa-Canto, E., A.A. Alonso, Banga, J.R. 2010. An iterative identification procedure for dynamic modelling of biochemical networks. BMC Systems Biology.4:11.
Franco-Uría, A. Otero-Muras, I., Balsa-Canto, E., Alonso A.A., Roca E. 2010. Generic parameterization for a pharmacokinetic model to predict Cd concentrations in several tissues of different fish species. Chemosphere. 78(4): 377-386
Otero-Muras, I. A. Franco, A.A. Alonso, Balsa-Canto, E. 2010. Dynamic multi-compartmental modelling of metal bioaccumulation in fish: Identifiability implications. Environmental Modelling & Software. 25: 344-353
Sendin, J.O.H., A.A. Alonso, Banga, J.R. 2010.Efficient and robust multi-objective optimization of food processing: A novel approach with application to thermal sterilization. Journal Food Engineering.98(3): 317-324
Alonso, A.A., Antelo, L.T., Otero-Muras, I., Perez-Galvez, R. 2010 Contributing to Fisheries sustainability by making the best possible use of their resources: the BEFAIR initiative. Trends in Food Science and Technology. 21: 569-578
A. Fernández Villaverde, A. Barreiro, C. Raimúndez. Noviembre 2010. Passive position error correction in
Internet-based teleoperation. Automatica. 46: 1884-1890
Vera, J., O. Rath, E.
Balsa-Canto, J. R. Banga, W. Kolch and Olaf Wolkenhauer. 2010. Investigating dynamics of inhibitory and feedback
loops in ERK signalling using power-law models. Molecular BioSystems 6(11):2174–2191
Rodriguez-Fernandez, M. and
J.R. Banga. 2010. SensSB: A software toolbox for the development
and sensitivity analysis of systems biology models. Bioinformatics 26(13):1675-1676.
Sendin, J.O.H., O. Exler
& J.R. Banga. 2010. Multi-objective mixed
integer strategy for the optimisation of biological networks. IET Systems Biology 4(3):236-248.
Egea,
J.A., Martí, R., & Banga, J.R. 2010. An
evolutionary method for complex-process optimization. Computers and Operations Research 37(2):315-324.
J. Ross, A.
Fernández Villaverde.
Thermodynamics and Fluctuations far from Equilibrium. Octubre 2010. Entropy 12: 2199-2243
BOOKS
Georgiadis, Michael C., Julio
R. Banga and Efstratios N. Pistikopoulos .2010. Dynamic process modelling. Wiley-VCH, Weinheim, ISBN-10: 3-527-31684-1
CHAPTERS IN BOOKS
López-Quiroga E., Antelo L.
T., Alonso A. A.
2010. Model reduction as a tool for robust predictive
control: application to OPR. 20h European Symposium on Computer
Aided Chemical Engineering (ESCAPE-20) - ISBN:
978-0-444-53718-8
Antelo L. T., Franco-Uría A., Alonso A. A. 2010. Optimal
networking of fishing actor to organise a responsible, optimal and sustainable exploitation of marine resources. PRES2010 Conference Proceedings, 4, 1430-1431. ISBN: 978-80-02-02249-7.
Antelo L. T., Balsa-Canto E., Trelea C., Alonso, A. A. 2010. Towards efficient operation
of freeze-drying processes through real time optimization. ECCE7 & CHISA2010
Conference Proceedings. ISBN: 978-80-02-02210-7 (2010).
Balsa-Canto
E., J.R. Banga and M.R. García 2010. Dynamic Model
Building Using Optimal Identification Strategies, with Applications in
Bioprocess Engineering. In " Process Systems Engineering Vol. 7 : Dynamic
Process Modeling ", Banga J.R., Georgiadis M., Pistikopoulos E. (eds.),
Wiley-VCH, Weinheim.
Balsa-Canto,
E., Banga, J.R.
2010. Computational Procedures for Model Identification. In
"Systems Biology for Signaling Networks", Sangdun Choi (Ed.), (pp:
111-138), Springer. ISBN:
978-1-4419-5796-2.
A.
A. Alonso, M. R. Garcia, C. Vilas 2010. Dynamic Modeling and Simulation for Robust Control of Distributed
Processes and Bio-processes. In “Process Systems Engineering Vol. 7 : Dynamic
Process Modeling", Banga J.R., Georgiadis M., Pistikopoulos E. (eds.),
Wiley-VCH, Weinheim.
Papers in Journals (2005-2009)
2009
Egea J.A., Balsa-Canto E., García M.R.., Banga J.R. 2009. Dynamic optimization of nonlinear processes with an
enhanced scatter search method. Industrial
and Engineering Chemistry Research, 48(9):4388-4401.
Egea, J. A., Vazquez, E., Banga, J. R., Martí, R. 2009. Improved scatter
search for the global optimization of computationally expensive dynamic models.
Journal of Global Optimization,
43(2-3): 175-190.
Escaño, J.M.,
C. Bordons, C. Vilas, M.R. Garcia, Alonso, A.A. 2009. Neurofuzzy
model based predictive control for thermal batch processes. Journal of Process
Control, 19: 1566-1575
Hirmajer T.,
Balsa-Canto E., Banga J.R.
2009. DOTcvpSB, a software toolbox for dynamic optimization
in systems biology. BMC Bioinformatics, 10:199.
Kucherenko
S., Rodríguez-Fernández M., Pantelides C.C., Shah N. 2009. Monte Carlo evaluation of Derivative based Global
Sensitivity Measures. Reliability
Engineering & System Safety, 94: 1135-1148.
Otero-Muras,
I., Banga, J.R., Alonso, A.A. 2009. Exploring
multiplicity conditions in enzymatic reaction networks. Biotechnology
Progress, 25(3): 619-631.
Otero-Muras I, Franco-Uría A., Alonso A.A.,
Balsa-Canto E. 2009. Dynamic multi compartmental modelling of metal
bioaccumulation in fish: Identifiability implications, Environmental Modelling
and Software. Environmental
Modelling & Software, 25(3): 344-353
Rodriguez-Fernandez, M.,
Banga, J. R. 2009. Global sensitivity
analysis of a biochemical pathway model. Advances
in Soft Computing 49:233-242
Schlüter, M., Antelo, L. T., Egea, J. A., Alonso, A.
A., Banga, J.R. 2009. An Ant Colony Optimization
based algorithm for the integrated process and control system design. Industrial and Chemistry
Engineering Research, 48(14): 6723-6738.
Schlüter, M., Egea, J. A., Banga, J. R. 2009. Extended ant colony optimization for non-convex
mixed integer nonlinear programming. Computers & Operations Research, 36(7): 2217-2229.
Sendín, J.O.H., Alonso, A.
A., Banga, J. R. 2009. Multi-objective
optimization of biological networks for prediction of intracellular fluxes. Advances in Soft Computing 49:197-205.
Sendín, J. O. H., Banga, J.
R., & Csendes, T. 2009. Extensions of a multistart clustering algorithm for
constrained global optimization problems. Industrial
and Engineering Chemistry Research 48(6):3014-3023.
2008
Álvarez-Vázquez LJ,
Balsa-Canto E, Martínez A. 2008. Optimal design and
operation of a wastewater purification system. Mathematics and Computers in Simulation, 79 : 668-682.
Antelo LT, Banga JR, Alonso AA. 2008. Hierarchical design of decentralized control structures for the
Tennessee-Eastman process. Computers & and Chemical Engineering, 32: 1995-2015.
Antelo LT, Exler O,
Banga JR, Alonso AA. 2008. Optimal Tuning of Thermodynamic-Based Decentralized PI Control Loops:
Application to the
Balsa-Canto E, Alonso
AA, Banga JR. 2008. Computational
procedures for optimal experimental design in biological systems. IET Systems Biology, 2(4): 163-172.
Balsa-Canto E, eifer
M, Banga JR, Timer J, Fleck C. 2008. Hybrid optimization
method with general switching strategy for parameter estimation. BMC Systems Biology, 2 (26).
Balsa-Canto E, Alonso AA,
Banga JR. 2008. Computing optimal dynamic experiments for model
calibration in predictive microbiology. Journal of Food Process Engineering, 31: 186-206.
Banga JR. 2008. Optimization in computational systems biology. BMC Systems Biology, 2: 47.
Banga JR, Balsa-Canto E, Alonso
AA. 2008. Quality and safety models and optimization as part of
computer-integrated manufacturing. Comprehensive
Reviews in Food Science and Food Safety, 7: 168-174.
Banga JR, Balsa-Canto
E. 2008. Parameter estimation
and optimal experimental design. Essays
in Biochemistry, 45: 195-209.
Csendes T, Pal L,
Sendin JOH, Banga JR. 2008. The GLOBAL
Optimization Method Revisited. Optimization Letters, 2
(4): 445-454.
Exler O, Antelo LT, Egea JA, Alonso
AA, Banga, JR.
García MR, Vilas C, Banga JR, Alonso
AA. 2008. Exponential Observers for Distributed Tubular (Bio)Reactors. AIChE Journal, 54 (11): 2943-2956.
Ignatova MN, Lyubenova VN, García MR, Vilas C, Alonso AA. 2008. Indirect adaptive linearizing control of a class of bioprocesses- Estimator tuning procedure. Journal
of Process Control, 18 (1): 27-35.
López R, Balsa-Canto E,
Oñate E. 2008. Neural networks for
variational problems in engineering. International Journal
for Numerical Methods in Engineering, 75 (11): 1341-1360.
Otero-Muras I, Szederkényi G, Hangos KM, Alonso AA. 2008. Local dissipative Hamiltonian description of reversible reaction
networks. Systems and Control Letters,
57: 554-560.
Otero-Muras I, Szederkényi G,
Hangos KM, Alonso AA. 2008. Dynamic analysis and control of biochemical reaction networks. Mathematics and Computers in Simulation,
79: 999-1009.
Scheerlinck N,
Vilas C, García MR, Banga JR, Alonso
AA. 2008. Desarrollo de una
Librería de Componentes en EcosimPro para
Vilas C, García MR,
Banga JR, Alonso AA. 2008. Robust feed-back control of travelling waves in a class of
reaction–diffusion distributed biological system. Physica D: Nonlinear phenomena, 237
(18): 2353-2364.
2007
Antelo, LT; Otero-Muras, I; Banga, JR;
Alonso, AA. 2007. A systematic approach to plant-wide control based on thermodynamics. Computers & Chemical Engineering 31
(5-6): 677-691.
Antelo L.T., Otero-Muras I., Banga J.R., Alonso A.A. 2007. La
teoría de redes en ingeniería de control: aplicación al análisis dinámico y al
control de procesos. Revista
Iberoamericana de Automática e Informática Industrial, 4(1): 24-34.
Balsa-Canto,
E; Rodriguez-Fernandez, M; Banga, JR.
2007. Optimal
design of dynamic experiments for improved estimation of kinetic parameters of
thermal degradation. Journal of Food
Engineering 82 (2): 178-188.
Egea, JA; Rodriguez-Fernandez, M; Banga, JR;
Marti, R.
2007. Scatter search for chemical and bio-process optimization. Journal of Global Optimization 37 (3): 481-503.
Egea, J.A., D. Vries, A.A. Alonso, J.R.
Banga 2007. Global Optimization for Integrated Design and Control of Computationally
Expensive Process Models. Industrial
& Engineering Chemistry Research 46(26):9148-9157
Garcia, MR; Vilas, C; Banga, JR; Alonso, AA. 2007. Optimal field
reconstruction of distributed process systems from partial measurements. Industrial & Engineering Chemistry
Research 46 (2): 530-539.
Rodriguez-Fernandez, M; Balsa-Canto, E;
Egea, JA; Banga, JR. 2007. Identifiability and robust parameter estimation in food process
modeling: Application to a drying model. Journal
of Food Engineering 83 (3): 374-383.
Vera, J; Balsa-Canto, E; Wellstead, P;
Banga, JR; Wolkenhauer, O. 2007. Power-law
models of signal transduction pathways. Cellular
Signalling 19 (7): 1531-1541.
Vilas, C; Garcia, MR; Banga, JR; Alonso, AA. 2007. Robust feed-back
control of distributed chemical reaction systems. Chemical Engineering Science 62 (11): 2941-2957.
2006
Vilas, C., García, M.R.,
Banga, J.R., Alonso, A.A. 2006 Stabilization of inhomogeneous patterns in a diffusion-reaction system
under structural and parametric uncertainties. Journal of
Theoretical Biology
241(2): 295-306
García, M.S.G., Balsa-Canto,
E., Banga, J.R., Alonso, A.A. 2006 Computing optimal
operating procedures for the food industry. Journal of Food Engineering 74:
13- 23
Garcia, M. S. G.,
Balsa-Canto, E., Vande Wouwer, A., Banga, J. R. 2006 Dynamic
Optimization of a Simulated Moving Bed (SMB) Chromatographic Separation Process. Industrial
& Engineering Chemistry Research 45(26):
9033-9041.
Rodríguez-Fernández, M.,
Egea, J. A., Banga, J. R. 2006 Novel Metaheuristic for
Parameter Estimation in Nonlinear Dynamic Biological Systems. BMC
Bioinformatics 7: 483
Rodriguez-Fernandez, M.,
Mendes, P., Banga, J.R. 2006 A hybrid approach for
efficient and robust parameter estimation in biochemical pathways.
BioSystems 83(2-3): 248-265.
Sendín, J.O.H., Otero, I.,
Alonso, A.A., Banga, J.R. 2006 Improved optimization methods
for the multiobjective design of bioprocesses. Industrial &
Engineering Chemistry Research 45(25):
8594-8603.
Sendin, O. H., Vera, J.,
Torres, N.V., Banga, J.R. 2006 Model Based Optimization of
Biochemical Systems Using Multiple Objectives: A Comparison of Several Solution
Strategies. Mathematical and Computer Modelling of Dynamical Systems 12
(5): 469-487
2005
Balsa-Canto,
E., Alonso, A. A., Banga, J. R. (2005) Dynamic optimization of complex
distributed process systems. Chemical Engineering Research and Design
83(A8): 1–6.
Banga, J.
R., E. Balsa-Canto, C. G. Moles and A. A. Alonso (2005) Dynamic optimization of
bioprocesses: Efficient and robust numerical strategies. Journal of Biotechnology
117(4):407-419.
Balsa-Canto,
E., Vassiliadis, V. S., Banga, J. R. (2005) Dynamic Optimization of Single- and
Multi-Stage Systems Using a Hybrid Stochastic-Deterministic Method. Industrial
and Engineering Chemistry Research 44(5):1514-1523.
COLLABORATIONS
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Stanford University, USA
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Carnegie Mellon University, USA
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Princeton University, USA
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Imperial College, Londres
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Katholieke Universiteit Leuven, Bélgium
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Université Catholique de Louvain, Belgium
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CNRS Montpellier, France
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Institu Pasteur, París
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ETH Zurich
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Faculté Polytechnique de Mons, Belgium
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Computer and Automation Research Institute, MTA-SZTAKI, Budapest
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Institute of Control and Systems Research (Bulgarian Academy of
Sciences)
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University of Aberdeen, Reino Unido
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University of Rostock
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University of Freiburg
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University of
Munich
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Max-Planck-Institute
for Complexity, Magdeburg
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Max-Planck-Institute for Molecular Genetics, Berlin
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University of Szeged, Hungría.
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Supélec (École Supérieure d'Électricité), Paris, Francia.
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INRA, París
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Universidad Politécnica de Valencia
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Universidad Complutense de Madrid
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Universidad de Valladolid
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Universidad de Sevilla
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Universitat de València